降压胶囊对老年单纯收缩期高血压血清一氧化氮合酶活性、丙二醛水平及血浆神经肽Y、同型半胱氨酸浓度的影响

Effect of Jiangya Capsule on Levels of Serum Nitric Oxide Synthase Activity, Malondialdehyde, Plasma Neuropeptide Y and Homocysteine in Patients with Senile Simple Systolic Hypertension

目的 :观察降压胶囊对老年单纯收缩期高血压 (EISH)患者血清一氧化氮合酶活性 (NOS)、丙二醛 (MDA)及神经肽Y(NPY)、血浆同型半胱氨酸 (Hcy)浓度的影响。方法 :采用随机、双盲对照法将患者分为两组 ,治疗组采用降压胶囊治疗 ,对照组采用尼莫地平治疗 ,观察血压变化 ,并进行血清NOS、MDA及血浆NPY、Hcy浓度的测定。 结果 :两组降压疗效相似 ,差异无显著性 (u =0 2 4 ,P >0 0 5 ) ;对临床中医证候的影响 ,治疗组总有效率 90 % (18/2 0 ) ,对照组总有效率 6 0 % (9/15 ) ,组间比较差异有显著性 (u =2 18,P <0 0 5 )。治疗组治疗后能提高NOS活性 ,降低血清MDA、血浆Hcy及NPY水平 ,与治疗前比较差异均有显著性 (P <0 0 5 ,P <0 0 1) ,其改善程度均优于对照组 (P <0 0 5 ,P <0 0 1) ,而对照组在降低血清MDA方面与治疗前比较差异有显著性 (P <0 0 5 )。结论 :降压胶囊对EISH有较好疗效 ,能提高NOS活性 ,降低血清MDA水平 ,能明显降低血浆Hcy、NPY浓度。

Objective: To observe the effect of Jiangya Capsule (JYC) on serum levels of nitric oxide synthase (NOS) activity and malondialdehyde (MDA), and plasma concentration of neuropeptide Y (NPY) and homocysteine (Hcy) in patients with senile simple systolic hypertension. Methods: Randomized, double-blinded controlled method was adopted, the patients were divided into two groups, the treated group treated with JYC and the control group treated with Nimodipine. Changes of blood pressure, serum level of NOS and MDA, and plasma concentration of NPY and Hcy were observed. Results: The effect of lowering blood pressure in the two groups were similar with insignificant difference (u=0.24, P>0.05). The total effective ratio in alleviating TCM syndrome was 90% (18/20) in the treated group and 60% (9/15) in the control group, comparison between them showed significant difference (u=2.18, P<0.05). After treatment, the NOS activity increased and MDA, NPY and Hcy levels decreased in the treated group, which showed significant difference as compared with those before treatment, and the improvement were better than those in the control group (all P<0.05 or P<0.01). While in the control group after treatment, only level of MDA was lowered significantly (P<0.05). Conclusion: JYC has good effect in treating senile simple systolic hypertension, it also could increase the NOS activity, lower the serum MDA level, obviously reduce the plasma concentration of Hcy and NPY.