广谱抗生素应用对小婴儿肠道微生态的影响

THE EFFECT OF WIDE-SPECTRUM ANTIBIOTICS ON THE MICRO FLORA IN YOUNGER INFANT

目的 :探讨抗生素对小婴儿肠道微生态的影响 ,评价便涂片法监测小婴儿肠道菌群变化的可行性。方法 :对 3 0例应用广谱抗生素治疗的 3个月以下小婴儿 (试验组 )及 3 2例同年龄正常儿 (对照组 ) ,用便涂片直接镜检法进行肠道菌群的初步分析和监测。结果 :应用抗生素 3～ 15d,试验组革兰阴性杆菌比例明显下降 ,革兰阴性杆菌生长受抑制 ,革兰阳性球菌渐表现出优势生长。因此 ,对应用抗生素的患儿应尽早应用微生态制剂调整肠道菌群。结论 :应用便涂片直接检菌法可帮助临床医生初步判定小婴儿肠道菌群的变化情况 ,简便、经济。

Objective:To investigate the effect of o n the micro-flora in younger infant.Methods:30 wide-spectrum antibiotics treated infant less than 3 months old(experiment group) and 32 age m ahched normal infant were enrolled We analyzed the stool coccid and bacteria af t er excrement gram dying under microscope Results:The infant int estinal flora was confused after using wide-spectrum antibiotic for 3～5 days.T h e G - bacilli decreased significantly (P<0 05),G + bacteria increased re markblely(P<0 05). It suggests that the rcoimminonurition should be used ea rly in infant who receives wide-spectrum antibiontic treatment.Conclusi on:Stool bacteria counting after gram dying under microscope is a simpl e practical and economical method on the evaluation of intestinal flora in infan t.Which can be used in clinic works.