孕产妇及胎婴儿巨细胞病毒感染的分析

An Analysis of Cytomegalovirus Infection in Pregnant Women and Their Infants

采用间接免疫酶组化法检测1253例孕妇和40例有反复流产、畸胎、死胎史的优生咨询者及14例孕妇巨细胞病毒IgM(HCMV-IgM)阳性的新生儿脐血的HCMV-IgM。结果:孕妇HCMV-IgM阳性率为8.06％,16例反复流产者阳性3例,13例畸胎史者阳性5例,11例死胎史者阳性2例。14例新生儿脐血阳性11例。提示HCMV感染与致畸、自然流产,死胎有密切关系,新生儿可从HCMV-IgM阳性的母亲获得先天性感染。

1 253 pregnant women and 40 eugenic counseling patients with repeated abortion or malformation parturition or stillbirth parturition and 14 new-borns with their mothers' HCMV-IgM antibodies positive were assessed by using an indirect immunoperoxdase technique. It was found that positive rate of pregnant women was 8.06%. There were 3 positive in 16 patients with repeated abortion, and 5 positive in 13 patients with malformation parturition, and 2 positive in 11 patients with stillbirth parturition. HCMV-IgM antibodies positive occurred in 11/14 cord sera. There was close relation between HCMV infection and malformation or natural abortion or stillbirth. Newborns were infected congenitally from their mothers with HCMV-IgM antibodies positive.