摘要
应用脉冲多普勒超声心动图(FDE),评价硝苯吡啶对30例单纯左向右分流型先天性心脏病患儿的左心搏血量(Vs)、右心搏血量(Vp),体循环血流量(Qs)、肺循环血流量(Qp)及肺,体循环血流比值(Qp/Qs)的影响。结果发现,用药后中到大量分流组的Vs、Qs增加和Qp/Qs比值减小,经统计学处理,均有非常显著性意义(P<0.001);小分流组的Vs、Qs和Qp/Qs的变化均无显著性意义。研究表明,PDE容积血流测定技术是评价儿科临床心血管药物疗效的可靠手段;硝苯吡啶可增加中到大量左向右分流型先心病的Vs和Qs,减少左向右分流,改善心功能。
The hacmodynamic effects of nifedipine were evaluated in 30 children with left-to-right congenital heart disease (CHD) by pulsed Doppler echo-cardiography (PEE). The observed variables include left ventricular stroke volume (Vs), right ventricular stroke volume (Vp), systemic blood flow (Qs), pulmonary blood flow (Op) and pulmonary to systemic blood flow ratio (Qp/Qs). The results show that nifedipine can significantly increase the Vs, Qs, and significantly decrease the Qp/Qs in the moderate to large left-to-right shunt CHD. It is reasonable to assume that PDE is a reliable means of assessing the efficacy of cardiovascular drugs in pediatric clinic.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1992年第3期165-167,共3页
Acta Universitatis Medicinae Tongji
关键词
心脏缺损
硝苯吡啶
超声心动图
Doppler, echocardiography
heart defects, congenital
nifedipine
