山茛菪碱对绞窄缺血肠段肠系膜微循环作用的实验观察

The Effect of Anisodamine on Mesenteric Microcirculationof Strangulated Ischemic Intestinal Segments:Experimental Observations

本实验用兔制成绞窄性肠梗阻的动物模型,用微循环显微镜观察肠系膜微循环的变化。解除梗阻后缺血肠段肠系膜微循环在一段时间内存在明显障碍,并伴有肠粘膜缺血性损伤。肠系膜根部加静脉应用山茛菪碱,能明显扩张细动脉,加快血流,改善肠系膜微循环,促进肠管生机恢复。以减少术后肠穿孔的发生。

Animal model of strangulated intestinal obstruction was produced in rabbits. Microcirculation states in strangulated intestinal mesentery were mic-roangioscopically observed before and after the obstruction was formed. There were still some disorders in mesenteric microcirculation of ischemic intestinal segments after release of strangulated obstruction, which were accompanied by the injury of ischemic intestinal mucosa. Injection of Anisodamine into the radicle of mesentery, as well as intravenous drip of its, could apparently improve the function of mesenteric microcirculation, that is, increase blood perfusion and dilate arterioles. Therefore, the viability of intestinal segments could be restored more rapidly, and the chances of intestinal perforation be reduced after operation.