用于肿瘤放射免疫显像的^(99)Tc^m标记抗体

^(99)Tc^m-LABELLED ANTIBODIES FOR RADIOIMMUNOIMAGING OF TUMORS

一、前言目前,^(131)I和^(111)In仍是放射免疫显像诊断肿瘤中应用最多的二种放射性核素。尽管放射性碘标记蛋白质的技术已经相当成熟,但碘标记抗体的缺点是碘易在体内脱落。并且,^(131)I的物理半衰期较长,发射β^-射线,从抗体上脱落的游离碘还易被甲状腺集中吸收,这些都会增加病人的照射剂量。^(111)In作为诊断用核素具有合适的物理半衰期和γ射线能量,并且经二乙三胺五乙酸(DTPA)引入的^(111)In与抗体的结合通常是牢固的。但实际工作表明,^(111)

This overall review concerns the preparation, present preliminarily clinical test results, and its future application of ^(99)Tc^m-labelled antibodies (^(99)Tc^m-Abs) for tumor radioimmunoimaging (RII). Techniques of radiolabelling antibodies with ^(99)Tc^m by both direct and indirect methods are summarized. Factors related the clinical application of ^(99)Tc^m-Abs; including antibody preparation, radiolabelling techniques, radiopharmakinetics etc., are analysed, and several new potential ways for successful RII using ^(99)Tc^m-Abs are recommended.