浅析血清GPDA、CEA联合检测对胃癌的诊断价值

Evaluation of combining detection of glycly proline dipeptidyl aminopeptidase and cancer embryo antigen (CEA)in diagnosing stomach Carcinoma

目的评价血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)、癌胚抗原(CEA)联合检测在胃癌诊断中的临床意义。方法收集40例健康人血清和56例胃癌及35例非胃癌患者血清分别测定GPDA、CEA含量,以GPDA≤28.6U/ml、CEA≥80ng/ml为胃癌阳性预示值。结果胃癌患者GPDA(30.6±14.8)显著低于健康对照组(68.8±20.2)(P<0.01)。对胃癌的诊断阳性率GPDA为71.4%、CEA为51.8%,若二项联合检测阳性率为82.1%,特异性为95.1%,诊断有效率为92.1%。结论血清GPDA、CEA联合检测可明显提高胃癌的阳性检出率。

Objective To evaluate the clinical significance s of glycly proline dipeptidyl aminopeptidase(GPDA)and cancer embryo antigen(CEA)in diagnosing stom-ach Carcinoma.Methods Serum GPDA and CEA from56samples of the patients with stomach Carcinoma,35samples with other diseases and40samples of healthy people were detected respectively,taking GPDA≤28.6U/L CEA≥80ng /ml as the positive value for predicting stomach Carcinoma.Results The levels of serum GPDA,(30.6±14.8)in patients with stomach,significantly lower than those in healthy control(68.8±20.2)(P<0.01).The positive rates of GPDA,CEA in diagnosing stomach increased to71.4%,51.8%respectively.When combining the two items ,the positive rate was82.1%,the specifivity95.1%and diagnosing effictive rate92.1%.Con clusions Combining detec-tion of serum GPDA and CEA will significantly raise the positive rate in diagonsing stomach Carcinoma .