超声引导下多电极射频治疗肝癌的临床研究

A CLINICAL STUDY OF MULTIPLE-ELETRODES RADIOFREQUENCY ABLATION FOR HEPATIC CARCINOMA GUIDE BY ULTRASONOGRAPHY

目的 :探讨超声引导下多电极射频疗法对肝癌治疗的临床意义。方法 :对 6 4例肝癌患者进行 1 0 5次超声引导多电极射频治疗 ,定期进行肿瘤标志物、B超、CT检查。结果 :原发性小肝癌 2 5例 ,其中 AFP阳性 2 1例 ,多电极射频治疗后 1 7例转阴 ,4例下降 ;CT显示肿瘤完全液化 2 2例 ,根治率 88%,一年存活率 93.94 %。原发性大肝癌射频 +综合治疗组及单纯射频组术后一年生存率分别为 73.91 %、6 3.4 6 %。结论 :多电极射频疗法是治疗肝癌的一种新方法 ,具有微创、疗效短、安全、可靠、可反复多次进行的优点。尤其对小肝癌可接近或达到手术根治切除的效果 ,与手术、栓塞、高能聚焦等配合可更有效的治疗大肝癌 。

Objective:To study the value of ultrasonography guiding multiple electrodes radiofrequency ablation(RFA) for hepatic carcinoma.Methods:64 patients with primary or metastatic hepatic carcinoma were treated by RFA under ultrasound guidance through Leveen multipolar array needle electrode and RF2000 for 105 times. All patients were followed up by tumor marker,soundgraphy Type B and CT regularly.Result:In 25 patients with small primary hepatic carcinoma (≤5 0 cm),17 of 21 patients with AFP positive changed to normal,with 4 markedly,and CT showed the treated tumors were completely turned into necrosis in 22 patients(88%). The 1 year survival rate was 93 94% in small primary hepatic carcinoma,and 73 91% and 63 46% in large primary hepatic carcinoma groups(in Synthetic Method and in RFA).Conclusion:RFA is becoming a kind of new palliative treatment for hepatic carcinoma, which is safe,mini invasive,and effective especially for small hepatic carcinoma and can also be used in conjunetion with TACE or FEP for larger ones.