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^(18)F-fallypride:一种多巴胺D2受体PET显像剂 被引量：4

^(18)F-fallypride: an excellent dopamine D2 receptor imaging agent for PET
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摘要 18F-fallypride是一种新的多巴胺D2受体PET显像剂,它与多巴胺D2受体亲和力高(Ki=0.03nmol/L)、亲脂性适宜(logKw=2.43),适于纹状体及纹状体外多巴胺D2/D3受体显像。对其合成、药理作用及体内过程、临床应用等进行了综述。 F-fallypride is a novel dopamine D2 receptor imaging agent for PET. With the high affinity to dopamine D2 receptor (Ki=0.03 nmol/L) and moderate lipophilicity(logKw=2.43), it is suitable for visualizing both striatal and extrastriatal dopamine D2/D3 receptor binding in the brain. Its synthesis, pharmacology, distribution in vivo and clinic study are reviewed in this paper.
作者 杨敏 项景德 曹国宪
机构地区 江苏省原子医学研究所 江苏省原子医学研究所核医学国家重点实验室
出处 《国外医学（放射医学核医学分册）》 2003年第6期259-262,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 ^18F-fallypride 多巴胺D2受体 PET 显像剂 药理作用 dopamine D2 receptor 18F-fallypride positron emission tomography
分类号 R817.9 [医药卫生—影像医学与核医学]
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参考文献8

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同被引文献25

  • 1杨敏,项景德,王广基,曹国宪.^(18)F-Fallypride前体化合物的合成[J].中国医药工业杂志,2004,35(9):517-519. 被引量：2
  • 2张锦明,郭喆,田嘉禾,刘伯里.自动化合成^(18)F-FDDNP及其生物学分布[J].中华核医学杂志,2005,25(3):140-141. 被引量：11
  • 3边艳珠,张锦明,刘怀军,田嘉禾,姚树林.帕金森病模型猴^(11)C-Raclopride多巴胺D_2受体PET脑显像[J].中华核医学杂志,2005,25(3):146-148. 被引量：20
  • 4Siessmeier T, Zhou Y, Buchholz HG, et al. Parametric mapping of binding in human brain of D2 receptor ligands of different affinities. J Nucl Med, 2005,46 : 964-972.
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  • 8Mukherjee J, Yang ZY, Brown T, et al. Preliminary assessment of extrastriatal dopamine D2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, ^18F-Fallypride. Nucl Med Biol, 1999, 26: 519-527.
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国外医学（放射医学核医学分册）
2003年 第6期

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