摘要
18F-fallypride是一种新的多巴胺D2受体PET显像剂,它与多巴胺D2受体亲和力高(Ki=0.03nmol/L)、亲脂性适宜(logKw=2.43),适于纹状体及纹状体外多巴胺D2/D3受体显像。对其合成、药理作用及体内过程、临床应用等进行了综述。
F-fallypride is a novel dopamine D2 receptor imaging agent for PET. With the high affinity to dopamine D2 receptor (Ki=0.03 nmol/L) and moderate lipophilicity(logKw=2.43), it is suitable for visualizing both striatal and extrastriatal dopamine D2/D3 receptor binding in the brain. Its synthesis, pharmacology, distribution in vivo and clinic study are reviewed in this paper.
出处
《国外医学(放射医学核医学分册)》
2003年第6期259-262,共4页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)