麻黄汤不同配伍对乙酰胆碱致豚鼠离体气管痉挛的抑制作用

Inhibition of varible compatibility of Mahuangtang to trachea spasm by acetylcholine

目的 :通过观察麻黄汤不同配伍对乙酰胆碱致豚鼠离体气管平滑肌痉挛的抑制作用 ,研究麻黄与方中诸药之间的关系 ,为继续深入研究组方打下基础。方法 :使用 PCL AB生物信号采集系统 ,记录正常豚鼠气管螺旋条张力的变化 ,观察比较各组药物对乙酰胆碱致离体气管螺旋条收缩的解痉百分率。结果 :单方麻黄解痉百分率最高 ,其次为麻黄、杏仁和甘草组合 ,与盐水对照组差别有显著性意义 (P <0 .0 5 )。结论 :方中其它药物对麻黄的药理作用有影响。

Objective: By investigating the inhibition of the different compatibility of Mahuangtang to trachea spasm by acetylcholine,we studied the relationship befween Herb Ephedrae and other herbs in the same prescription and provided foundation for the further reseach. Method:The tension of the nomal guinea pig trache was read by PCLAB biological signal system. Antispasm percent of every compatibility was detected and compared.Result:Antispasm percent of the decoction of Herb Ephedraealone was the highest ,the next was the compatibility of Herb Ephedrae with Almond and Licorice root, with significance campared with NS group (P<0.05). Conclusion: The other herbs in the prescription have some influence on the pharmacological effect of Herb Ephedrae.