胃癌患者术前免疫状态及影响因素

IMMUNE STATE AND INFLUENTIAL FACTORS IN PATIENTS WITH GASTRIC CANCER BEFORE OPERATION

通过检测50例胃癌患者和30例非肿瘤患者外周血NK细胞活性和T细胞亚群来研究胃癌患者术前免疫状态及其影响因素。结果显示:术前胃癌患者免疫功能明显低于非肿瘤患者,而且胃癌患者免疫功能随着病期的进展呈进行性下降,但其免疫状态与肿瘤类型无明显直接关系,与患者的年龄、性别也无关系。而肿瘤患者术前免疫状态与肿瘤病灶大小有直接关系,即病期越晚,肿瘤病灶越大,免疫功能越低。这进一步提示肿瘤患者的免疫抑制是肿瘤源性的,可能由肿瘤细胞分泌的免疫抑制因子所造成。因此应尽可能地切除肿瘤组织以改善患者的免疫状态。

For analysing the immune state and influential factors in patients with gastric cancer before operation,NK cell activity and T - lymphocyte subsets in periphral blood were tested in 50 cases gastric cancer patients and 30 cases non - tu-morous patients. The results showed that before operation the immune function of the patients with gastric cancer was lower than non-tumor patients,and also decreased progressively with the deterioration of the disease before operation. However, there was neither direct correlation between the degree of malignancy and the pre- operation immune state and nor direct cor-relation between the pre -operative immune state and sex or age of the patients. The results suggested that the pre- operation immune state was directly correlated with the size of the tumor,the more advanced stage and larger tumor,the lower immune function. This further indicates that the immunosuppression originated from the tumor,the hypoimmunity was basically at-tributed to the immune inhibition fator from tumorous cells,which means the necessity of the removal of tumorous tissue to improve the immune state of the patients.