抗癌基因P53突变和周期素与膀胱移行细胞癌的关系

CORRELATION BETWEEN THE MUTATION OF ANTI - ONCOGENE P53 CYCLIN AND TRANSITIONAL CELL CARCINOMA OF BLADDER

对52例膀胱移行细胞癌,8例正常膀胱粘膜和8例慢性膀胱炎组织,应用抗周期素单克隆抗体和抗P53蛋白单克隆抗体,进行免疫组织化学染色。结果表明癌细胞的分化程度与P53的表达与否密切相关。分化较高的Ⅰ级膀胱移行细胞癌,P53的阳性率仅为20.8％,而分化较差的Ⅲ级癌,阳性率高达83.3％(P<0.05)。周期素的表达在非癌组织和各级膀胱移行细胞癌之间的差别非常显著(P<0.01),其表达程度可用于炎性增生和癌的鉴别。

Using the monoclonal antibodies of cyclin and P53,the authors analyzed their expression in 52 cases of transi-tional cell carcinoma of bladder, 8 normal bladder tissues and 8 chronic cystitis. It was showed that there was a closed corre-lation between the expression of P53 and grade differentiation in the transitional cell carcinoma of bladder. The positive rate of P53 in grade I transitional cell carcinoma with well differentiation was 20. 8% , however that of gradeⅡtransitional cell carcinoma with bad differentiation was 83. 3% (P<0. 01). There was statistically significant different of the expression of cy-clin between the non - carcinoma tissues and transitional cell carcinoma of bladder (P<0. 01).