谷胱甘肽S—转移酶Pi同功酶对消化道肿瘤诊断意义的再探讨

GO FURTHER INTO THE SIGNIFICANCE OF DETECTING PI CLASS GLUTATHIONE S - TRANSFERASE IN SERUM FOR DIAGNOSIS OF GASTROINTESTINAL CARCIONOMA

采用双抗夹心ELISA检测了113例正常人、485例消化道恶性肿瘤、80例消化系外肿瘤和368例相应器管的非癌疾病患者血清谷胱甘肽S—转移酶Pi同功酶(GST_(Pi))含量。结果恶性肿瘤患者血清GST_(pi)较正常人非癌疾病组显著增高(P<0.001),GST_(pi)作为肿瘤标志物不具有器官特异性,但对鉴别同一器官疾病的良、恶性具有辅助诊断价值。肝癌患者癌细胞分化程度愈高,病程愈晚,血清GST_(Pi)升高愈显著。从胃粘膜癌前病变到早期胃癌、晚期胃癌,血清GST_(pi)逐步增高,说明血清GST_(pi)测定对癌前病变的监测可能有用。

Serum of 113 normal subjects,485 cases of carcinoma of the GI tract,80 cases of carcinoma of other systems and 368 cases of benign diseases were tested for the levels of serum Pi class glutathione S-transferase (GSTpi). It was found that the serum level of GSTpi was elevated in each groups patients with carcinoma. The patients with benign diseases had nor-mal GSTpi. But some patients with chronic hepatitis, cirhosis and atrophic gastritis with serious heterotypic hyperplasia had slightly elevated levels. Serum GSTpi assays provide a sensitive but no-specific marker for gastrointestinal malignancies. These patients with well-differentiated hepatocellular cancer had higher serum GSTpi levels than those with poorly differenti-ated. The mean serum GSTpi levels in advanced stomach cancer than that in early,and the latter had a higher serum GSTpi lev-els than that with preneoplastic lesions. These results indicate that serum GSTpi detection is helpful to supervise the patients with preneoplastic lesions of the gastric mucosa.