C-erbB-2原癌基因的表达与食管癌患者的预后

EXPRESSION OF C-erbB-2 PROTOONCOGENE IN ESOPHAGEAL CARCINOMA IN RELATION TO PROGNOSIS

应用抗c-erbB-2蛋白单克隆抗体,对41例食管癌中c-erbB-2原癌基因的表达进行免疫组化检测。结果表明,c-erbB-2癌蛋白在正常食管粘膜为阴性,而在食管癌中增强表达为51.2％(21/41),并与组织学分级、淋巴结转移关系密切(P<0.05,P<0.01)。c-erbB-2癌蛋白阳性的食管癌患者预后差,术后5年生存率明显低(P<0.05)。结果提示:c-erbB-2原癌基因蛋白可成为一项判定食管癌预后有价值的参考指标。

The expression of c-erbB-2 protooncogene of esophageal carcinoma in 41 cases was assayed with SP immunohis-tochemistry using c-erbB-2 protooncogene monoclonal antibady. In specimens of normal esophageal mucosa negative results was revealed, whereas overexpression of c-erbB-2 oncogene presented in 21/41 (51. 2%) of the esophageal carcinoma with specific ralation with pathologic grade and lymph node metastasis (P<0. 05 or P<0. 01). The patients survival analysis showed that prognosis of patients with esophageal carcinoma with c-erbB-2 oncogene was poorer and survived lower (P<0. 05). It is conclud-ed that the expression of c-erbB-2 oncogene might serve as an useful indicator for evaluating the prognosis of esophageal carcinoma.