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PCNA和p53在大肠肿瘤中的表达及其临床意义 被引量:1

EXPRESSION OF PCNA AND p53 IN COLORECTAL TUMOUR AND ITS CLINICAL SIGNIFICIENCE
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摘要 作者采用ABC免疫组化法分别检测了10例正常大肠粘膜、20例腺瘤、60例癌组织中的PCNA、p53的表达量,结果显示:(1)大肠癌组织中PCNA强阳性表达率(63.3%)>腺瘤(20%)>正常粘膜组(0%);p53阳性表达率大肠癌组(58.3%)>腺瘤组(15%)>正常粘膜组(0%)P<0.05;(2)存活5年以下大肠癌组PCNA强阳表达率(83.3%)、p53阳性表达率(80%)>存活5年以上大肠癌组(43.3%·36.7%)P<0.01;(3)PCNA表达量与大肠癌患者淋巴结转移正相关,与组织类型、浸润深度无关,p53表达量则均不相关;(4)PCNA在大肠癌中的表达与p53表达正相关,而在腺瘤中的表达则不相关。提示PCNA、p53的表达多少不仅可辅助大肠良恶性病变的鉴别,且可辅助评估大肠癌患者的预后。 The expression of PCNA and p53 in the tissues of 10 cases of control normal mucosa, 20 cases of colorectal ade-noma and 60 cases of colorectal cancer were detected respectively by using immunohistochemistry method. The results were showed as fallowing:①The rate of the strong positive expression of the PCNA in the colorectal cancer (63. 3%)>that in the col-orectal adenoma (20%)>that in the normal colorectal mucosa (0%). The rate of the positive expression of the p53 in the col-orectal cancer (58. 3%)>that in the colorectal adenoma (15%)>that in the normal colorectal mucosa (0%),P<0. 05. ② The rate of the strong positive expression of the PCNA in that of the living under-5-year patients (83. 3%) was more than that of the living over-5-year patients (43. 3%). The rate of positive expression of the p53 in that of the living over-5-year patients (36. 7%) was lower than that of the living under-5-year patients (80%) ,P<0. 01. ③ The expression of the PCNA have straight rela-tionship with lymphnode metastasis, but no relationship with histological classification and the depth of the invasion. The expres-sion of the p53 has no relationship with above three factors.④ The expression of PCNA in the tissues of colorectal cancer has straight relationship with expression of p53 has no relationship with in the tissue of colorectal adenoma. These results indicated that not only did the expression of the PCNA and p53 can assist differential diagtnosis between colorectal benign and malignant tumour, but also evaluate the prognosis of the patient with colorectal cancer.
出处 《临床肿瘤学杂志》 CAS 1996年第3期7-9,共3页 Chinese Clinical Oncology
关键词 PCNA P53 大肠肿瘤 免疫组化 增殖细胞核抗原 Clinical Significance, PCNA, p53, Colorectal Tumour
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