支气管肺泡灌洗液细胞学检查在周围型肺癌诊断中的价值

VALUE OF BRONCHOALVEOLAR LAVAGE IN CYTOLOGIC DIAGNOSIS OF PERIPHERAL LUNG CANCER

目的:探讨BAL在肺癌诊断中的价值。方法:37例肺癌患者作BAL,最后一次灌洗用含。—糜蛋白酶液,BALF不过滤,离心涂片后分别以瑞氏、巴氏和HE法染色后镜检。结果:10例患者的BALF中找到瘤细胞,其中胸片弥散型与结节型阳性率分别为6/10和4/27(P<0.05),以含。—糜蛋白酶液灌洗阳性6例。瑞氏,巴氏和HE染色法的单一阳性数分别为0,1,2例。结论:BAL在周围型肺癌诊断中有一定的辅助价值,联合巴氏和HE染色法能提高检出率而。α—糜蛋白酶无助于提高阳性率。

Purposes: Objectives to evaluate bronchoalveolar lavage (BAL) in cytologic diagnosis of lung cancer. Methods: 37 patients of lung cancer were performed BAL lastly with α-chymotrypsin liquor. The cytocentrifuge slides of unfilltered BALF were stained with Wright, Papanicolou and HE stain respectively and examined by experienced cytopathologists. Results: Malig-nant cells were found in 10 patients, the diagnostic positive rate was higher in patients with an infiltrative lesion on the chest ra-diogram than in those showing a peripheral nodule (6/10 vs 4/27, P<0. 05). There were 6 samples positive in α-chymotrpsin-in-voled fluid lavaged ones. Wright, Papanicolou and HE stain gave the only postive result in 0,1,2 patients respectively. Conclu-sions: BAL plays an effective assistant role in the cytologic diagnosis of peripheral lung cancer. Combination of Papanicolou-stain with HE-stain can increase the positive while α-cymotrysin was not helpful to increase it.