血清层粘连蛋白水平与肺癌浸润关系研究

THE STUDY OF SERUM LAMININ LEVEL AND ITS RELATIONSHIP WITH LUNG CANCER INFILTRATION

本文用固相酶联免疫检测方法(EIASA)对42例肺癌患者血清层粘连蛋白(LN)含量进行测定,探讨其与肺癌病情的关系。结果发现,肺癌患者血清LN水平较正常人显著升高,其水平随肺癌浸润转移程度的增加而升高;小细胞肺癌患者血清LN水平较非小细胞肺癌亦明显增高,化疗可使小细胞肺癌患者血清LN水平显著降低。结果提示,血清LN水平随肺癌浸润转移程度的增加而升高,它可作为反映肺癌患者病情轻重、评估,临床预后及疗效的良好指标。

Serum laminin (LN) level were assayed using ELISA method in 42 patients with lung cancer. The results indicat-ed that the serum LN level in lung cancer patients were highly elevated than the normal persons, and it is in accordance with the degree of infiltration and metastasis in lung cancer patients. Serum LN level in small cell lung cancer patients were also higher than non-small cell lung cancer patients. Serum LN level in patients with small cell lung cancer are decreased significantly after chemotherapy. All these indicated that Serum LN can be served as a good marker to assess the severness, make prognosis, and judge the effectiveness to treatment in lung cancer patients.