肺硬化性血管瘤临床病理分析

CLINICAL PATHOLOGICAL STUDY OF SCLEROSINGHEMANGIOMA OF THE LUNG

目的 :探讨肺硬化性血管瘤 ( SHL)的临床病理特点及性质 ,提高对 SHL的诊断水平。方法 :对 1 2例经手术切除的 SHL进行临床和病理资料的回顾性分析 ,用免疫组化 LSAB法检测了 EMA、SMA、KP-1、vi-mentin、Cg A、S-1 0 0和 CD3 4在其石蜡切片中的表达。结果 :除 CD3 4阴性外 ,其余 6种抗体均有不同程度的阳性表达。提示此瘤是由上皮和间质及少数神经内分泌细胞等多种成分的混合性炎性增生。其无包膜 ,生物学行为具有一定的自限性。结论 :SHL是炎性假瘤的特殊类型 ,而非真性肿瘤。

Objective: To investigate the clinicopathologic features and the nature of sclerosing hemangioma of the lung (SHL) and to raise the level of diagnosis of the diseases. Methods: The clinicopathologic data of 12 cases with SHL were reviewed retrospectively and immunohistochemistry stains were applied to paraffin sections by using EMA、SMA、KP-1、vimentin、CgA、S-100 and CD34 antibodies with labeled strept-avidin-biotin method(LSAB). Results: CD34 antibody was negative in the cases of SHL. The other 6 antibodies were positive expression in different degree in the cells of the cases of SHL, which showed that the tumors were formed by mixed inflammatory hyperplasia mainly including epithelial cells, various kinds of mesenchymal cells and a few neuroendocrine cells and so on. The SHL had no capsule and there were some features of self-restriction in its biological behavior. Conclusion: SHL is rather a kind of inflammatory pseudotmuors than a real tumor.