肝硬化患者血浆内源性类洋地黄物质与肝功能的关系

Relationship of the Level of Plasma Endogenous Digoxin-like Substance with Liver Function of Liver Cirrhosis

目的:探讨肝硬化患者血浆内源性类洋地黄物质(EDLS)水平与肝功能的关系。方法:用放免法检测24例正常人和61例肝硬化患者血浆EDLS。结果:肝硬化组血浆EDLS水平显著高于对照组(P均<0.001),且在肝功能分级中,呈现Child C>Child B>Child A的规律。相关分析显示肝硬化者血浆EDLS与血浆白蛋白水平间呈明显负相关,与总胆红素间呈明显正相关。结论:肝硬化者血浆EDLS水平能够反映肝硬化肝功能损害的严重程度。

Objective:To investigate the relationship of the level of plasma endogenous digoxin-like substance to liver function of cirrhosis. Method: EDLS was measured in plasma samples collected from 24 healthy controls and 61 liver cirrhosis patients. Results: Plasma EDLS of cirrhotic patients was significantly higher than those of healthy controls( P< 0 . 001). Comparisions of the level of plasma EDLS among the various groups of liver cirrhosis classified by liver function were shown as follows:Child C>Child B>Child A(P<0.05) . The concentration of EDLS covaried negatively with that of plasma albumin and positively with those of plasma AST or total biliru-bin. Conclusion:The level of plasma EDLS of liver cirrhosis may reflect the severity of liver damage.