茶色素对原发性肾病综合征患者内皮素和肾功能的影响

Effect of tea pigment(茶色素) to the endothelin and renal function in patients with primary nephritic syndrome

目的 :探讨茶色素对原发性肾病综合征 (PNS)患者血、尿内皮素和肾功能的影响与机制。方法 :将 6 5例 PNS患者随机分成治疗组 (33例 )与对照组 (32例 )两组。对照组采取常规疗法 ,治疗组在常规疗法基础上加用茶色素治疗 ,每日 3次 ,每次 2 4 0 m g,两组疗程均为 8周。观察治疗前后患者血、尿内皮素 (ET)含量和肾功能变化。结果 :两组治疗前 PNS患者的血和尿 ET水平均无显著性差异 (P均 >0 .0 5 ) ,但均高于健康人组(P均 <0 .0 1) ,治疗后两者水平均显著改善 ,但治疗组治疗后血、尿 ET含量较对照组明显下降 ,差异有显著性(P<0 .0 1和 P<0 .0 5 ) ;两组治疗后肾功能也有明显的改善 ,但治疗组治疗后血尿素氮、肌酐较对照组下降更为明显 (P均 <0 .0 5 )。结论 :PNS在常规疗法基础上加用茶色素更能降低血、尿 ET,改善和保护肾功能。

Objective: To study the effect and mechanism of tea pigment(茶色素) on endothelin(ET) in plasma and urinary and renal function of primary nephritic syndrome(PNS) patients. Methods: Sixtyfive cases of PNS were randomly divided into therapeutic group(33 cases) and control group(32 cases). The control group was treated by normal treatment, and the therapeutic group was treated by tea pigment on the basis of normal treatment, and tea pigment was given 240 mg three times daily. The therapeutic course was 8 weeks both in two groups. The blood and urine ET and the change of the renal function were observed. Results: The blood and urine ET of PNS patients in both two groups were obviously higher than those of the healthy people before the treatment (both P<0.01). After the systematic treatment, the blood and urine ET of PNS patients had been obviously decreased in both two groups. But, the urine and blood ET of PNS patients in therapeutic group decreased significantly than those in control group. The differences between two groups were significantly (P<0.05 and P<0.01). After the treatment, the renal function in both two groups had been greatly improved. But, the blood urea nitrogen and creatinine decreased more obviously than those in control group ( both P<0.05). Conclusion: On the base of general treatment, adding tea pigment to cure PNS will decrease the ET in blood and urine, improve and protect the renal function.