生长抑素结合中药治疗对重症胰腺炎患者免疫调节因子水平影响

The Influence on Immune Modulatory Factors of Patients with Acute Severe Pancreatitis Treated by Combined with Somatostastin and traditinal Chinese Medicine

目的 :探讨早期应用清营汤治疗对重症胰腺炎患者免疫调节因子水平的影响。方法 :采用酶联免疫法测定重症胰腺炎患者用清营汤加施他宁及单用施他宁治疗前后的外周血清中IL - 2、IL - 2Rα、sIL - 2R ,IL - 10、L - 12、IL - 18水平。结果 :重症胰腺炎早期联用清营汤组治疗 1周后 ,IL - 2、IL - 2Rα迅速上升 ;sIL - 2R、IL - 10、IL - 12、IL - 18水平下降明显 ;而施他宁对照组IL - 2及IL - 2Rα水平呈下降趋势 ,sIL - 2R、IL - 10、IL - 12、IL - 18水平下降变化不明显 ,两组结果相比差异显著。结论 :早期应用清营汤结合施他宁治疗重症胰腺炎患者 。

Objective: To study the effects of Qinyingtang, Traditional Chinese Medicine Preparation therapy on IL-2 system and IL-10?IL-12?IL-18 in patients with severe acute pancreatitis. Methods: 58 patients with acute severe pancreatitis were divided into two groups. 30 patients treated by Qinyingtang combined with somatostastin and 28 patients only treated by somatostastin. Cytokines levels of patients before and after treated in serum were detected by ELISA assay. Results: IL-2?IL-2Rα levels were increased markedly and sIL-2R, IL-10, IL-12, IL-18 levels were decreased variously in Qinyingtang group one week later ;IL-2 and IL-2Rα levels were decreased variously,sIL-2R levels no change in intravenous infusion group. IL-2?IL-2Rα and sIL-2R levels of patients with severe acute pancreatitis were obviously different in early oral Qinyintang. Conclusion:Early Qinyingtang therapy combined with somatostastin was helpful to restore the immuno-regulatory function of patients with severe acute pancreatitis and provided some experimental evidence of their early Qinyingtang therapy.