复方甲硝唑片含量测定方法的比较

Comparison of Content Determination Methods for Compound Metronidazole Tablets

文章经选择适当的测定波长,同时采用系数倍率法和联立方程组新解法不经提取分离直接测定复方甲硝唑片中甲硝唑和维生素B_6的含量。同时采用河北省药品标准法进行了对比测定。利用SPSS统计软件通过对各方法的测定结果做方差分析,结果表明:新建立的系数倍率法和联立方程组新解法的测定结果无显著性差异,而两法分别与河北省药品标准法的测定结果比较,均存在显著性差异。作者认为:河北省药品标准法经过烦琐的提取分离过程,引入的误差较大。而新建立的两法简便、快速、准确,优于河北省药品标准法。

With appropriate wavelength selection, the contents of components in compound metronidazole tablets may be determined by signal multiplier spectrophotometry and the new solution of simultaneous equations in spectrophotometry without any preliminary separation. At the same time, the assay of compound metronidazole tablets was done using Hebei pharmaceutical standard. Determination results of the methods were tested by SPSS statistical software. It turned out that the results of the two new methods do not show significant difference, however, when compared with Hebei pharmaceutical standard, a significant difference exists. We think that there might be bigger errors in of Hebei pharmaceutical standard, because it has to undergo complicated preliminary separation. The new methods are simple, rapid and accurate, and are better than Hebei pharmaceutical standard.