呼吸机相关性肺损伤的炎症反应机制

Inflammatory response mechanisms of ventilator-induced lung injury

机械通气是治疗急性呼吸窘迫综合征的主要手段 ,但呼吸机应用不当也可能加重原有的肺损伤 ,引起呼吸机相关性肺损伤。呼吸机相关性肺损伤本质上是生物伤 ,异常的机械力作用于细胞 ,激活细胞内信号转导通路 ,活化炎性细胞 ,产生大量炎症介质 ,加重炎症反应。探讨呼吸机相关性肺损伤的炎症反应机制 ,阻断机械力作用向细胞内的传导和细胞内信号转导途径的激活 ,减少炎症细胞的激活和炎症介质基因的表达 。

Mechanical ventilation is an important therapeutic approach to treat acute respiratory distress syndrome. Inappropriate use of ventilator will aggravate the prime injury of lung and cause ventilator-induced lung injury (VIL-I). So VIL-I is a biotrauma. Abnormal mechanical forces activate the intracellular signal transduction pathways, activate the inflammatory cells, produce lots of inflammatory mediators and aggravate inflammatory responses. The prevention of VIL-I can be implemental by inhibiting extracellular mechanical force conduction and intracellular signal transduction activation, and there by reducing inflammatory cells activation and inflammatory mediators gene expression.