梗阻性黄疸患者胆道内、外引流手术前后血清白细胞介素的表达及临床意义

Serum IL-6 and IL-12 levels and their significances in obstructive jaundice patients before and after internal or external biliary drainage

了解梗阻性黄疸胆道内、外引流术式对血清白细胞介素 - 6 (IL 6 )和白细胞介素 - 12 (IL 12 )含量的影响。方法 :4 3例由恶性肿瘤引起的梗阻性黄疸中 ,胆道内引流 32例 ,胆道外引流术 11例 ,4 3例患者术前、术后均测得血清IL 6和IL 12含量。结果显示 ,梗阻性黄疸内、外引流术前血清IL 6和IL 12低于正常组 ,行胆道内引流术后血清IL 6、IL 12的值与正常组比较无显著性差异 ,表明其免疫功能有所恢复 ,而胆道外引流术后血清IL 6、IL 12的值低于正常组 ,表明免疫功能仍受损。该结论提示在临床上对于一般情况差 ,不能行根治手术的梗阻性黄疸病人 。

To evalute the level of serum IL-6 and IL-12 of obstructive jaundiced patients before and after-operation. Serum IL-6,IL-12 were detected in 43 cases of obstructive jaundice patients, 32 cases with inner and 11 cases with outer drainage operation. The level of serum IL-6,IL-12 in preoperation were lower than that in normal group. The level of serum IL-6,IL-12 in inner drainage after-operation were equal to the normal group. But the serum IL-6 and IL-12 in outer drainage were lower than those in normal group(P<0 05). So inner drainage operation in the obstructive jaundice neoplasm should be the choice.