摘要
目的分析成人HIV/AIDS患者CD4^+细胞数与病毒载量(VL)之间的关系。方法对1990年—2001年在本院就诊的200例HIV/AIDS患者进行跟踪分析。结果 CD4^+≥200/μl时,血浆VL(log10)为4.17±0.79;CD4^+<200/μl时,血浆VL(log10)为5.01±0.72,VL水平明显高于CD^+≥200/μl组(P<0.01)。其中CD4^+>350/μl时,血浆VL(log10)为3.95±0.82;CD4^+200～350/μl时.血浆VL(log10)为4.43±0.63;CD4^+100～200/μl时,血浆VL(log10)为4.85±0.68;CD4^+<100/μl时,血浆VL(log10)为5.16±0.68。结论 HIV/AIDS患者CD4^+细胞数与病毒复制有非常密切的关系,外周血CD4^+细胞数与血浆VL的变化呈负相关关系。当血浆VL(log10)>5.01±0.72时,应考虑患者已进入艾滋病期。
Objective To analyze relation of plasma HIV viralload to the change of CD4+ lymphocyte count in adult HIV/AIDS patients. Method A total of 200 HIV/AIDS patients treated in our hospital from1990 to 2001 were analyzed. Results Plasma HIV viralload (log10) was 4.17 ± 0. 79 when CD4+ ≥200/μl, and plasma HIV viralload (log10) was 5.01 ±0.72 when CD4+ <200/μl. Plasma HIV viralload of CD4+ <200/μl group was significantly more than that of CD4+≥200/μl (P<0.01). Plasma viralload (log10) was 3.95±0.82, 4.43±0.63, 4.85±0.68, 5.16 ±0.68, respectively, in patients with CD4+ >350/μl, 200-350/μl , 100-200//J, < 100/μl, correspondingly. Con-clusion There is a close relationship between CD4 + count and HIV replication in progressive patients, and it shows a reverse linear correlation between CD4 + count and plasma HIV viralload. It may be considered as an important predictor of entering into AIDS when plasma HIV viralload(log10)>5.01 ±0.72.
出处
《传染病信息》
2003年第4期175-176,共2页
Infectious Disease Information
