新疆地区HBV感染者的血清学模式与HDV的关系

Relationship between serological mode and HDV infection in patients with HBV infection in Xinjiang

目的了解新疆地区乙乙肝炎病毒(HBV)感染者的血清学模式与丁型肝炎病毒(HDV)的关系,为新疆乙型肝炎病毒指标阳性病例的各民族(汉族162例、维族93例、哈族53例、回族32例、蒙古族28例)病毒性肝炎诊断、治疗提供可靠的流行病学资料。方法应用国产酶联免疫法(ELISA)和荧光定量聚合酶链反应(FQ-PCR),检测了新疆各地区不同民族HBV的血清学模式、HBV DNA和HDAg、抗-HD。结果在368例各族患者血清中,48例HDV血清标志物阳性,HBV血清学模式为HBsAg+、HBeAg+、抗-HBc+22例;HBsAg+、抗-HBe+、抗-HBc+18例;HBsAg+、抗-HBc+8例。结论新疆地区各民族HBV感染者中,HDV阳性标志物与HBV血清学模式、HBV DNA之间比较,P>0.05,并无显著性差异。

Objective To study the relationship between serological mode and HDV infection in 368 patients of different nationalities (including 28 Mongolian, 162 Han, 93 Uygur, S3 Kzak and 32 Hui patients) with HBV infection in Xinjiang to provide reliable epidemiological evidence for diagnosis and treatment of viral hepatitis. Methods ELISA and FQ-PCR were used to determine the serological mode of patients with HBV infection and levels of HBV DNA, HDVAg and anti-HD antibodies in patients of different nationalities in Xinjiang. Results Of the 368 patients, 48 were HDV-positive. Of these 48,22 were HBsAg + ,HBeAg+ and anti-HBc+ ,18 HBsAg+ , anti-HBe+ and anti-HBc+ and 8 HBsAg+ and anti-HBc + . Conclusion In HBV-infected patients of different nationalities in Xinjiang, the HDV positive markers are not significantly related to HBV serological modes.