变应性鼻炎、哮喘患者血白细胞介素的循证医学研究

Evidence-based medicine of research into the relationship between allergic rhinitis and asthma and adults Serum interleukin

目的 评价变应性鼻炎、哮喘患者血清中白细胞介素IL-4、IL-6、IL-8检测指标的意义。方法 检索策略:通过中国生物医学文献数据库(CBMdisc)、中文全文数据库全面检索国内已发表的相关文献。选择标准:中国成人变应性鼻炎、哮喘患者与对照组血清白细胞介素IL-4、IL-6、IL-8水平检测。资料收集和分析:由2位评价者按照上述检索策略收集文献。排除那些不符合选择标准要求的试验。结果 经Meta分析,发作期、缓解期变应性鼻炎患者血清中IL-4水平分别较对照组上升129.45 ng/mL(95％CI 124.95～133.96)、35.00 ng/mL(95％CI 32.01～39.78),有显著统计学意义(P<0.000 01):缓解期IL-6水平较对照组上升21.87 ng/mL(95％CI 19.83～23.91),有显著统计学意义(P<0.000 01);发作期、缓解期IL-8水平分别较对照组上升41.75 ng/mL(95％CI 29.14-54.36)、98.94 ng/mL(95％CI 96.48-101.41),有显著统计学意义(P<0.000 01);发作期IL-4水平较缓解期上升129.99 ng/mL(95％CI 125.00～134.99),有显著统计学意义(P<0.000 01)。结论 IL-4、IL-6和IL-8参与了变应性鼻炎、哮喘的发生和促进了变态反应性疾病的发展,有必要开展更广泛研究和更深层的原因探索。

Objective To evaluate the effect of interleukin, IL-4, IL-6 and IL-8 in adult serum examination in patients with allergie rhinitis and asthma. Method The search for all the related literature in CBMdisc has been made and Chinese full text database has been made. Selection criteria:Examination of serum interleukin, IL-4,IL-6 and IL-8 in Chinese adult patients with allergic rhinitis and asthma and control groups. Data collection and analysis: A quantitative meta-analysis was carried out by two reviewers using updated information based on inclusion and exclusion criteria from all paper available. The meta-analysis was based on interleukin, IL-4, IL-6 and IL-8. Results The numbers of IL-4 in attack phase and abirritative phase of the patients were significantly more than those in the healthy control group 129.45 ng/mL(95%CI 124.95-133.96),35.00 ng/mL(95%CI 32.01-39.78)(P<0.000 01) respectively. The numbers of IL-6 in abirritative phase of the patients were significandy more than those in the healthy control group 21.87 ng/mL (95%CI 19.83-23.91 )(P<0.000 01). The numbers of IL-8 in attack phase and abirritative phase of the patients were significantly more than those in the healthy control groups 41.75 ng/mL(95%CI 29.14-54.36),98.94 ng/mL(95%CI 96.48-101.41)(P <0.000 01) respectively. The numbers of IL-4 in attack phase of the patients were significantly more than those in abirritative phase of the patients 129.99 ng/mL (95%CI 125.00-134.99)(P<0.000 01). Conclusion IL-4,IL-6,IL-8 play a role in the pathophysiological of allergic rhinitis and asthma.