摘要
目的 :观察不同类型冠心病患者中可溶性CD4 0配体 (sCD4 0L)的变化 ,并探讨其与血脂各组份的关系。方法 :采用酶联免疫吸附法测定 12 9例冠心病患者 (急性心肌梗死组 4 6例 ,不稳定性心绞痛组 37例 ,稳定性冠心病组 4 6例 )及 30名正常对照者血清sCD4 0L的浓度。结果 :急性冠脉综合征患者sCD4 0L水平 [急性心肌梗死组和不稳定心绞痛组分别为 (2 .99± 2 .19) ,(2 .2 3± .0 .6 7)ng/ml]显著高于稳定性冠心病组 [(1.12± 0 .4 2 )ng/ml,P <0 .0 5 ]和正常对照组 [(0 .89± 0 .5 5 )ng/ml,P <0 .0 5 ],而在稳定性冠心病组和NS组间差异无显著性 ;sCD4 0L水平与ApoB10 0 (r =0 .15 9,P =0 .0 4 6 )呈正相关 ,与高密度脂蛋白胆固醇呈负相关 (r = 0 .192 ,P =0 .0 15 )。结论 :急性冠脉综合征患者外周血sCD4 0L水平明显升高 ,这可能与急性冠脉综合征的发生有关 ,且可作为动脉粥样硬化斑块不稳定的一个标志。
Objective To investigate the serum level of soluble CD40 ligand(sCD40L) in coronary heart disease and its relationship with serum lipid levels. Methods Enzyme-linked immunosorbent assay (EIA) was used to measure sCD40L in 129 patients with coronary heart disease (46 with acute myocardial infarction, 37 with unstable angina pectoris and the other 46 with stable angina pectoris) and 30 matched healthy controls. Results sCD40L level was significantly higher in patients with acute coronary syndrome (ACS)[(2.99± 2.19 ),(2.23 ±.0.67) ng/ml in acute myocardial infarction and unstable angina pectoris group, respectively] than that of those with stable coronary heart disease and that of controls [(1.12± 0.42) and (0.89±0.55) ng/ml, respectively](P<0.05).Serum sCD40L level was significantly positively related to ApoB100 (r=0.159, P=0.046), and negatively related to HDL-C (r=-0.192, P=0.015). Conclusion The levels of sCD40L increase in acute coronary syndrome, which may be related to the pathogenesis of ACS , and can be used as a potential marker of plaque instability.
出处
《湖南医科大学学报》
CSCD
北大核心
2003年第6期611-614,共4页
Bulletin of Hunan Medical University
