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eIF-5A与hypusine 被引量：4

eIF-5A and hypusine
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摘要 翻译起始因子eIF_5A在真核细胞内普遍存在 ,是目前为止惟一发现含独特氨基酸hypusine残基的蛋白。hypusine是eIF_5A前体的特定赖氨酸残基 (第 5 0位 )经亚精胺依赖性的翻译后修饰形成的 ,每一成熟的eIF_5A仅含一个hypusine残基 ,eIF_5A的hypusine修饰是其发挥功能、细胞存活和增殖所必需的。本文对eIF_5A的研究历史、现状和hypusine功能的近期进展进行了概述 ,并进一步分析了eIF_5A的可能功能及hypusine修饰过程作为药物靶标诱导细胞凋亡的应用前景。 Eukaryotic translation initiation factor 5A (eIF-5A) is the only cell protein that contains the unusual basic amino acid hypusine. Hypusine formation on eIF-5A is essential for cell survival and proliferation, but the precise functions of eIF-5A and hypusine formation remain elusive. Agents that reduce cell hypusine levels inhibit the growth of mammalian cells. In this review the novel insights on the biochemical and molecular events leading to hypusine formation and its involvement in the cellular processes are summarized.
作者 靳宝锋 何昆 张学敏
机构地区 军事医学科学院基础医学研究所
出处 《军事医学科学院院刊》 CSCD 北大核心 2003年第6期463-466,共4页 Bulletin of the Academy of Military Medical Sciences
基金 国家高技术研究发展计划"863"资助项目( 2 0 0 1AA2 3 3 0 41)
关键词 EIF-5A HYPUSINE 蛋白质合成 细胞凋亡 eIF-5A hypusine protein synthesis apoptosis
分类号 R341 [医药卫生—基础医学]
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参考文献24

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同被引文献105

  • 1王转,臧庆伟,郭志爱,景蕊莲.小麦幼苗期水分胁迫所诱导基因表达谱的初步分析[J].Acta Genetica Sinica,2004,31(8):842-849. 被引量：31
  • 2张宏一,朱志华.植物干旱诱导蛋白研究进展[J].植物遗传资源学报,2004,5(3):268-270. 被引量：31
  • 3俞嘉宁,张林生,张劲松,山仑,陈受宜.小麦耐逆基因-TaLEA3的克隆及在酵母中的功能分析[J].生物工程学报,2004,20(6):832-838. 被引量：18
  • 4耿晓华,郭鲜花,左雅慧,王小莉,王仲文.γ射线诱发人正常肝细胞基因组不稳定性研究[J].中华放射医学与防护杂志,2007,27(2):135-138. 被引量：5
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  • 6Park M H. The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities [J]. J Biol Chem, 1989,264(31) : 18531-18535.
  • 7Liu Y P,Nemeroff M,Yan Y P,et al. Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus typel Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification [J ]. Neuro-Signals, 1997,6(3) : 166-174.
  • 8Park M H. The post-translational synthesis of a polyamine-de rived amino acid, hypusine,in the eukaryotic translation initia tion factor 5A(eIF-5A) [J]. J Biochem, 2006, 139 (2) : 161 -169.
  • 9Caraglia M, Tagiiaferri P, Budillon A, et al. Post-translational modifications of eukaryotic initiation factor-SA(elF-SA) as a new target for anti-cancer therapy [J]. Adv ExP Med Biol, 1999,472:187-198.
  • 10Chen Z P,Yan Y P,Ding Q J,et al. Effects of inhihitors of deoxyhypusine synthase on the differentiation of mouse neuro- blastoma and erythroleukemia cells [J]. Cancer Lett, 1996,105 (2) :233-239.

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军事医学科学院院刊
2003年 第6期

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