氟伐他汀对5/6肾切除大鼠肾脏的保护作用

Renoprotective Effect of Fluvastatin on 5/6 Nephrectomized Rats

目的 :探讨羟甲基戊二酰辅酶 A( HMG- Co A)还原酶抑制剂氟伐他汀 ( fluvastatin)对 5 /6肾切除大鼠肾脏的保护作用。方法 :将 5 /6肾切除大鼠 2 4只随机均分为 5 /6肾切除组 ,模型组 ( n=1 2 )和氟伐他汀治疗的 5 /6肾切除组 ,治疗组 ( n=1 2 ) ,另设假手术组作为对照组 ( n=6)。处理 1 3周后检测尿蛋白排泄率、血清尿素氮、肌酐、总胆固醇和甘油三酯含量 ,光镜和电镜检查肾形态改变并计算肾小球硬化指数。结果 :氟伐他汀治疗组大鼠尿蛋白排泄率、血清尿素氮和肌酐水平较模型组明显降低 ,肾脏病变和肾小球硬化程度明显减轻。结论 :氟伐他汀对 5

Objective: To investigate the renoprotective effect of fluvastatin, a 3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitor (HCRI), on 5/6 nephrectomized rats. Methods: Twenty four 5/6 nephrectomized (NX) rats were randomly divided into 5/6 NX rats (model group, n =12) and fluvastatin treated 5/6 NX rats (treatment group, n =12), and sham operated rats served as control (sham operation group, n =6). After fluvastatin was orally administered(7 mg·kg -1 ·d -1 ) for 13 weeks, urinary protein excretion, BUN, serum creatinine, total cholesterol(TC), and triglyceride(TG) contents were determined. The renal pathological lesion and glomerular sclerosis index (GSI) were studied. Results:The urinary protein excretion, BUN, and serum creatinine levels in treatment group were significantly lower than those in model group. Fluvastatin markedly ameliorated the renal pathological lesion and glomerular sclerosis. Conclusion: Fluvastatin shows a renoprotective effect on 5/6 nephrectomized rats.