慢性乙型肝炎患者血清HBV DNA水平变化及临床意义

Change of HBV DNA Level in the Sera of Patients with Chronic Viral Hepatic Disease and its Clinical Significance

目的 :探讨慢性乙型肝病患者血清 HBV DNA水平变化在慢性乙型肝病发生发展中的作用及临床意义。方法 :采用荧光定量 PCR( FQ- PCR)法检测慢性乙型肝炎 ( CHB)、慢性乙型重型肝炎 ( CSHB)、乙型肝炎性肝硬化 ( HBC)患者血清 HBV DNA含量。结果 :HBV DNA含量随病情加重逐渐下降 ,CSHB组与 CHB、HBC组相比差异具有显著性 ( P<0 .0 1 )。结论 :慢性乙型肝病患者机体存在免疫功能调控失衡 ;动态观察 HBV

Objective: To observe the change of HBV DNA level in the sera of patients with chronic viral hepatic disease and its clinical significance. Methods:The amount of HBV DNA in the sera of patients with chronic hepatitis B (CHB), chronic severe hepatitis B (CSHB) and hepatic B cirrhosis (HBC) were measured with FQ PCR. Results: The level of HBV DNA in CSHB group was significantly lower than those in CHB and HBC groups ( P <0.01). The bilirubin level in the sera of patients with chronic viral hepatic disease of different clinical types had a inverse relationship with the level of HBV DNA. Conclusion: The patients with chronic viral hepatic disease had an unbalance on the regulation and control of immunologic function. The level of HBV DNA as well as the bilirubin level in the sera of patients can reflect the necrosis degree of liver cells.