1999-2002年四川省流感暴发分析

Analysis of Influenza Outbreak in Sichuan Province From 1999 to 2002

目的 了解四川省流感的流行动态、探索流行规律 ,为今后流感的防治提供科学依据及防治措施。方法 ①病原学 :用鸡胚分离、MDCK细胞培养、血凝实验。②血清学 :用血凝抑制实验。结果 1999- 2 0 0 2年共采集流感样患者标本 2 16人份 ,分离出流感病毒 33株 ,乙型 30株、甲 1型 3株 ,各占分离总数的 90 91% (30 /33)、 9 0 9% (3/33)。 4年共采集流感样患者急性期、恢复期血清各 93人份。 2 0 0 0年 6 1份、 2 0 0 1年 16份、 2 0 0 2年 16份。分别对A1型抗体 4倍增长率为 :2 6 2 3%、 10 0 0 0 %、 6 2 5 % ;对A3型抗体 4倍增长率为 :4 4 2 6 %、 12 5 % ;对B型抗体 4倍增长率为 :16 39%、 13 12 %、 81 2 5 %。结论 引起四川省近 4年流感暴发的毒株以乙型为主 ,且时间主要集中在每年的 1～ 4月和 9～ 11月。

Objective To determine the epidemic trends of influenza and explore the regulation of influenza activity,to provide the scientific bases and measure for influenza prevention in the future Methods ①Aetiology: the virus was isolated by chick embryos,MDCK cell culture and haemagglutination assay (HA) ②Serology:haemagglutination Inhibition Assay (HI) Results From 1999 to 2002,totally 216 blood samples of patients with as like influenza had been collected and 33 strains had been isolated,subtype B 30 strains and subtype A1 3 strains Respectively,which is 90 91%(30/33),9 09%(3/33) During four years, we totally collected 93 acute and convalescent blood samples of patients with as like influenza, respectively 61 in 2000, 16 in 2001, 16 in 2002. Respectively,antibody of subtype A14 fold increase rate is 26 23%,100 00%,6 25%,subtype A3 44 26%,12 5% and subtype B 16 39%,13 12%,81 25% Conclusions The subtype B is the main strain which caused the outbreak of influenze in Sichuan province in recent 4 years. And the outbreak occured from JAN to APR and from SEP to Nov in each year.