冠心病患者血清高敏C-反应蛋白、血脂水平研究

Relationship between serum high-sensitivity C-reactive protein and lipid screening in coronary heart disease

目的 探讨血清中高敏C 反应蛋白、血脂浓度与冠心病 (CoronaryHeartDisease,CHD)的关系及临床意义。方法 测定CHD患者共 1 1 9例 ,其中不稳定型心绞痛 (UA)患者 5 3例 ,稳定型心绞痛 (SA)患者 6 6例及正常对照组 30例 ,血清高敏C 反应蛋白 (High SensitivityC ReactiveProtein ,Hs CRP)、总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白A1 (apoA1 )、载脂蛋白B(apoB)浓度。结果 UA、SA患者的血清Hs CRP含量显著高于正常对照组 (P<0 .0 1 ) ,其中UA组患者血清Hs CRP水平又明显高于SA组患者 (P <0 .0 1 ) ;UA患者apoA1 浓度明显低于正常对照组 (P <0 .0 1 ) ,SA患者apoA1 浓度较正常对照组低 (P <0 .0 5 ) ,其余结果无差别。结论 血清Hs CRP、apoA1 水平与冠心病 。

Objective To investigate the relationship between serum high sensitivity C reactive protein (Hs CRP) and lipid levels in coronary heard disease (CHD).Methods We assessed the serum concentration of Hs CRP,TC,TG,HDL C,LDL C,apoA 1,apoB in 119 CHD patients and 30 normal subjects.Among the 119 patients with CHD,53 were unstable angina(UA) and 66 were stable angina(SA).Results Serum Hs CRP levels in UA,SA were significantly higher than that of controls ( P < 0.01 ),while Hs CRP levels in UA were significantly higher than that in SA ( P <0.01);apoA 1 levels in UA and SA were lower than that of controls ( P <0.01),( P <0.05).Conclusion The serum Hs CRP,apoA 1 levels are closely related to CHD,especially UA.