3203例胎儿的产前21-三体综合征超声筛查

Prenatal Screening with Ultrasonography in 21-Trisomy Syndrome in 3203 Cases of Fetus

目的 建立超声检测胎儿颈部软组织厚度 (nuchalskinfoldthickness ,NT)的正常参考值 ,探讨该项指标在产前检出染色体异常中 2 1 三体胎儿的价值。方法 经腹部超声测量 3 2 0 3例中晚孕期胎儿颈部软组织厚度 ,并进行统计分析。结果 初步得出 12～ 40孕周胎儿NT的参考值范围 ,应用该项指标超声检测 2 1 三体胎儿 ,其敏感性为66 67% ,特异性为 95 0 6% ,准确性为 95 0 0 %。结论 NT超声测值对 2 1

Objective To establish a referential numer ic al value of normal fetal nuchal skinfold thickness and to study the value of the Nuchal Skinfold Thickness (NT) of fetus in diagnosis of fetal 21-trisomy synd rome. Methods NT of 3202 fetuses form 12 to 40 week gestation were measured and the results were statistically analyzed. Results The preliminary referential parameters of the fetal nuchal skinfold thick ness in 12—40 week gestation were, respectively, 66 67 %, 95 06 % and 95 00 %. Conclusion The ultrasonographic measurement data presented here may serve as reference in prenatal screening of 21-trisomy syndrome.