UCP_2:解偶联蛋白家族的新成员

UCP_2:New member of uncoupling protein family

解偶联蛋白 2 (uncouplingprotein 2 ,UCP2 )是解偶联蛋白家族的新成员 ,位于线粒体内膜上的阳离子载体蛋白。它可以引起质子的渗漏 ,使氧化磷酸化解偶联 ,ATP合成减少 ,能量以热的形式散失。UCP2 广泛分布于人体各组织器官。UCP2 主要参与能量代谢和脂代谢调节 ,但其广泛分布和轻微解偶联作用提示它的意义可能不仅限于此。目前UCP2 与氧化损伤的关系以及在脏器疾病中的作用已引起人们的关注。本文概述UCP2 的分布、作用及其表达调节。

Uncoupling proteine 2 (UCP 2 ) is localized in the inner membrane of the mitochondria in diverse tissues which may decrease mitochondrial membrane potential , deprive the driving force of ATP synthase from catalyzing ATP synthesis and dissipate energy in the form of heat. The regulator of UCP 2 mRNA include free fatty acids, leptin and etc. The previous study were mainly concentrate on the regulatory function of UCP 2 on energy metabolism and lipid metabolism. But its various function was suggested by its characteristic of wild distribution and mild uncoupling . Now evidence is accumulating that UCP 2 may play a role in regulating mitochondial production of reactive oxygen species and in some visceral diseases.