摘要
目的 :观察消痔汤的抗炎及镇痛作用。方法 :采用二甲苯致小鼠耳部炎症肿胀方法、醋酸扭体法、热板法等实验方法 ,观察消痔汤的抗炎、镇痛作用。结果 :消痔汤剂量在 8.8,17.6g·kg 1 时 ,对二甲苯所致小鼠耳部炎症的抑制率分别为 3 7.3 9% ,5 7.96% ;对醋酸所致小鼠扭体次数的抑制率分别为 47.2 4% ,74.87% ;热板法证实消痔汤在给药后 1～ 6h能明显提高小鼠的痛阈值。结论 :消痔汤具有抗炎、镇痛作用。
Objective:To survey the anti inflammatory and analgesic effects of xiaozhitang , a decoction for the treatment of hemorrhoids. Methods:The anti inflammtory effect of the drug given by gastrogavage was tested by assessing its action against the inflammatory edema of the mouse ear induced by local smearing of dimethylbenzene. The analgesic effect of xiaozhitang , administered by gastrogavage as well, was assayed with the writhing and hot plate methods in mice. Results:The inhibition rate of the inflammatory edema of the mouse ear induced by dimethylbozene was 37.39%,57.96% when the dose of xiaozhitang was between 8.8,17.6 g·kg 1 ·d 1 . The inhibition rate of the pain caused by acetic acid in the mouse was 47.24%,74.87%. The pain threshold of the mouse was significantly elevated 1-6 h after the administration of the drug, as shown by the hot plate method. Conclusion: Xiaozhitang was shown to have anti inflammtory and analgesic effects.
出处
《医药导报》
CAS
2003年第12期840-842,共3页
Herald of Medicine
