硫酸镁治疗新生儿重症肺炎的临床研究及对血气血镁的影响

Clinical Study of Magnesium Sulphate Treating Severe Pneumonia of Neonate and its Effect on Blood Gas and Blood Magnesium

目的 为探讨硫酸镁治疗新生儿重症肺炎的临床效果及对血气血镁的影响。方法 采用 96例新生儿重症肺炎患儿随机分成治疗组 4 8例 ,对照组 4 8例 ,治疗组加用硫酸镁 30～ 5 0mg/(kg·d)加入 5 %葡萄糖 2 0ml静滴 ,持续 1h ,疗程3～ 8d ,同时监测血气血镁。结果 治疗组总有效率 79.2 % ,对照组总有效率 5 0 .0 % (P <0 .0 1) ,硫酸镁在改善症状 ,消除肺部体征及缩短住院时间和提高治愈率等方面优于对照组 ,治疗组病死率下降 ,同时血气恢复正常优于对照组 ,血镁含量治疗前后无变化。结论 硫酸镁治疗新生儿重症肺炎疗效显著 ,未发现明显副作用。

Objective To investigate the clinicial curativeness of magnesium sulphate in the treatment of severe pneumonia in neonates and its effect on blood gas and blood magnesium.Methods Ninety six Cases of severe pneumonia were randomly divided into the treatment group(48 cases)and the control group(48 cases).The patients in treatment group were treated by adding magnesium sulphate with an initial dose at 30～50 mg/kg qd and adding 5% glucose 20 ml intravenously.Constantly for 1 hour and continuously for 3～8 days. At the same time,the blood gas and blood magnesium were monitored.Results The total effective rates of the treatment group and of the control group were 79.2% and 50.0%,respectively ( P <0.01).The result showed that treatment group was better than control group in improving symptoms of pneumonia,removing rales in lungs,shortenning duration of hospitalization and enhancing cure rate.The mortality of the treatment group was obviously reduced.The normal convalescence of the blood gas was more excellent than that of the control group.The blood magnesium was not changing in treatment group.Conclusion The curatives of magnesium sulphate in the treatment of severe pneumonia is marked and not any side effects were seen.