胆结石、胆囊切除术与大肠癌关系的探讨

A Study of the Correlation between Cholelithiasis Cholecystectomy and Colorectal Carcinoma

目的 探讨胆结石、胆囊切除术与大肠癌的关系。方法 本院 1994年 10月～ 2 0 0 2年 12月共收治大肠癌患者 2 4 5例 (大肠癌组 ) ,同期收治其它肿瘤患者 4 6 5例 (对照组 ) ,并对两组胆结石、胆囊切除术的百分率进行对比分析。结果 大肠癌组有 4 4例 ( 17.96 % )存在胆结石及胆囊切除术 ,其中胆结石 38例 ( 15 .5 1% ) ,有胆囊切除术史 6例 ( 2 .4 5 % )。而对照组中有 17例 ( 3.6 6 % )存在胆结石及胆囊切除术 ,其中胆结石 15例 ( 3.2 3% ) ,有胆囊切除术史 2例 ( 0 .4 3% )。两组比较 ,有显著性差异 (P <0 .0 5 )。结论 提示胆结石、胆囊切除术是大肠癌的致病危险因素。

Objective To study the correlation between cholelithiasis cholecystectomy and colorectal carcinoma.Methods Two hundred and forty five cases of colorectal carcinoma(test group) and 465 cases of other tumors (control group) were reviewed.All cases in both groups were admitted into the second affiliated hospital of Jiangxi medical college during Oct.1994 to Dec.2002.Results There were 44 cases(17.96%)were confirmed with cholelithiasis and cholecystectomy in the test group.Among the 44 cases,38(15.51%)were of cholelithiasis and 6(2.45%)were of cholecystectomy.There were 17 cases(3.66%)were confirmed with cholelithiasis and cholecystectomy in control group.Among them,15 cases(3.23%)were of cholelithiasis and 2 cases(0.43%)were of cholecystectomy.The difference between the two groups was significant( P <0.05).Conclusion Cholelithiasis and cholecystectomy are risk factors for colorectal carcinoma.