乳腺癌患者人表皮生长因子受体2及p53表达对生存期和预后的影响

Effect of expression of p53 and Her2 of breast cancer on survival time and prognosis

目的:研究乳腺癌人表皮生长因子受体α(HER2),p53与生存期的关系,探讨其成为乳腺癌临床康复预后指标的可行性。方法:采用免疫组化法检测185例乳腺癌标本的HER2和p53的表达,并对其生存时间随访。结果:①有10年内预后随访资料者120例,其中死亡28例,失访65例。②HER2,p53的阳性总表达率分别为:57.8%和47.6%。③HER2和p53各级生存率曲线比较,统计学上有显著性差异,P值均小于0.01。0～Ⅲ级均数得分为:11.9286,6.5500,-5.5556,-7.2273和9.6604,-8.0625,-27.9167,-4.0000。④HER2或p53过度表达均与生存期负相关(P<0.05,OR=1.566和P<0.01,OR=1.581)。⑤HER2联合p53过度表达与生存期负相关(P<0.05,OR=1.374和P<0.01,OR=1.566)。结论:乳腺癌患者HER2或p53阴性表达的生存率高于阳性表达者,无论是单独或者联合高表达都降低乳腺癌患者的生存时间,是乳腺癌预后不良的指标。

AIM:To investigate the epidermal growth factor receptorαrelationship between the survival time and the expression of mutant p53 protein and HER2 of breast cancer patients, and discuss the feasibility of this markers becoming clinical rehabilitation prognosis for breast cancer. METHODS:Immunohistochemical staining for HER2 and p53 was performed on paraffin embedded tumor specimens obtained from 185 patients with breast cancer,and follow up studies were conducted and the survival time of the patients was recorded. RESULTS:①In 120 patients with complete followed up data, 28 patients had died, the other 65 patients hadn't got touch.②The positive rates of HER2 and p53 were 57.8%and 47.6%.③The survival rate curves of HER2/p53 were significant difference in statistics between each grade(P< 0.01).The mean scores of p53 and HER2 from 0-III grade were (11.928 6,6.550 0,-5.555 6,-7.227 3,P< 0.01) and (9.660 4,-8.062 5,-27.916 7,-4.000 0,P< 0.01).④The overexpression of either HER2 or p53 was in negative correlation with survival time(P< 0.05, OR=1.566 and P< 0.01,OR=1.581).⑤The overexpression of both HER2 and p53 were in negative correlation with survival time(P< 0.05, OR=1.374 and P< 0.01,OR=1.566). CONCLUSION:The survival rates of the breast cancer patients with negative HER2 or p53 are better than positive one. The high expression of mono or union of HER2 and p53 suggests a short survival time.It is a bad prognosis marker.