常压模拟高住低练对大鼠血清自由基及一氧化氮的影响

Effects of Simulated Normobaric“Living High-Training Low”on Serum Free Radical Indexes and Nitric Oxide in Rats

目的 :探讨常压下模拟高住 (海拔 30 0 0m)低练对大鼠血清自由基代谢及NO的影响。方法 :4 0只雄性SD大鼠随机分为四组 ,分别为低住安静组、低住低练组、常压高住安静组和常压高住低练组 ,测定 4周后的大鼠血清超氧化物歧化酶 (SOD)、丙二醛 (MDA)及一氧化氮 (NO)变化。结果 :4周常压模拟高住低练使大鼠血清SOD较低住低练组显著升高 (P <0 0 1) ;NO较常压高住安静组极显著升高 (P <0 0 1) ,与低住低练组相比无显著性差异 ;MDA较低住低练组极显著降低 (P <0 0 1)。结论 :4周常压模拟高住低练可以显著提高大鼠血清SOD、NO活性 。

Objective:To study the effects of simulated Living High(equivalent to 3000m altitude)-Training Low on serum free radical and nitric oxide metabolism in rats.Methods:Forty male Sprague-Dauley rats were randomly divided into Living-Low sedentary group (G1);Living Low-Training Low group (G2);normobaric Living-High sedentary group (G3) and normobaric Living High-Training Low group(G4).After four weeks,the level of serum superoxide dismutase(SOD),malondialdehyde (MDA) and nitric oxide (NO) were determined.Results:The level of serum SOD in G4 was significantly higher than that in G2(P<0.01).The level of serum NO in G4 was significantly higher than that in G3 (P<0.01),but no statistics difference was found between G4 and G2.The level of serum MDA in G4 was significantly lower than that in G2 (P<0.01).Conclusions:The results indicated that stimulated normobaric hypoxic training could improve the activity of SOD and NO and decrease serum lipid peroxidation.