幽门螺杆菌与一氧化氮及胃粘膜病理变化的关系

The Relationship of Helicobacter Pylori and the Level of Nitric Oxide with Gastric Mucosa Pathological Development

目的 :通过观察 Hp感染后血清 NO及 NOS水平变化及其对胃粘膜病理改变的影响 ,来探讨 Hp的可能致病机理。方法 :随机选取 Hp阳性患者 5 0例 ,Hp阴性患者 35例 ,病理学检查的同时检测其血清中 NO及 NOS的含量。结果 :Hp阳性组血清 NO和 NOS含量分别高于 Hp阴性组 (P<0 .0 1)。在 Hp阳性患者中 ,血清中 NO和 NOS含量在慢性炎症组明显低于其他 3组 (P<0 .0 5 )。但在 Hp阴性组中 ,慢性胃炎患者血清中 NO含量低于其他 3组 (P<0 .0 5 ) ,而血清中 NOS含量在各组之间无明显差异。结论 :Hp诱导的 NO表达水平可能与胃癌前期病变相关。除 Hp可导致 NO合成增加外 ,癌前期病变还可通过其他炎症介质激活 NO的产生途径。

Objective:To observe the effect of the level of nitric oxide in Helicobacter pylori infection patients, and the relationship of gastric mucosa Pathological development with them.Methods:50 cases with Hp infection were treated as positive group and 35 cases with Hp negative as control group. The serum level of nitric oxide (NO) and NOS were detected.Results:The level of NO and NOS in positive group were higher than them in negative group (P<0.01).The level of NO and NOS in active gastritis were apparently lower than pre-neoplasm diseases(P<0.05), such as atrophy, intestinal metaplasia and heterogenesis.Conclusion:Infection of Helicobacter pylori can induce elevation of nitric oxide synthesis(NOS), which produced NO, It is correlation with pathological development of gastric mucosa in chronic gastric diseases.