癫痫患者苯妥英钠血液浓度监测及临床意义

Measurment of Blood Phenytoin Sodium Concentration and Its Clinical Significance in Patients with Epilepsy

目的 :介绍了抗癫痫药物苯妥英钠 (DPH)血液浓度监测及临床意义 ,着重探讨 DPH单药的临床应用价值。方法 :对单药 DPH组、双药组、3种以上药物组进行了 DPH血液药物浓度监测。结果 :显示首次 3组有效率无明显差异 (P>0 .0 5 ) ;经调整 DPH血液浓度后 3组疗效比较 ,其单药组与双药组、3种以上药物组有效率有显著性差异 (P<0 .0 5 )。双药组与 3种以上组有效率无显著性差异 (P>0 .0 5 )。结论 :表明控制癫痫大发作与部分性发作单药组较双药组、3种以上药物组效果为佳。

Objective:To introduce the measurement of blood Phenytoin Sodium concentration and its clinical significance, with the emphasis on investigating the clinical applied value of PHT especially.Methods:Blood concentrations of PHT were measured in single DPH group, double medicines group, and in multiple medicines group,respectively.Results:The effective rate of each group showed no significant difference (P>0.05).After abjusting the blood concentration of PHT, the effective rate of single medicine group showed significnat difference with the other two groups.(P<0.05),but double medicines group and multiple medicines group didn′t show obvious difference (P>0.05).Conslusions:It showed that to control the full and part break out of epilepsy,the single medicine group was better than the double medicine group and multiple medicines group.