摘要
静脉注射 SPD10mg/kg,可增加豚鼠对哇巴因的耐受量;能预防急性心肌缺血诱发的大鼠及氯仿-肾上腺素引起的兔心律失常。腹腔注射SPD60mg/kg,可预防氯仿诱发的小鼠室颤。离体实验,发现SPD能抑制豚鼠乳头肌的收缩性,延长功能不应期,降低自律性,而对其兴奋性则无明显影响。
Intravenous injection of SPD 10 mg/kg could increase the tolerant dose of ouabain, and prevent the arrhythmias induced by acute myo-cardial ischemia in rats and that elicited by adrenaline-chloroform model in rabbits. SPD 60 mg/kg intraperitoneally could abolish the ventricular fibrillation produced by chloroform inhalation in mice. It inhibited the contractility, prolonged the functional refractory period and decreased the automaticity significantly of the isolated guinea pig papillary muscles, but no significant effect on excitability.
出处
《中国药理学通报》
CAS
1988年第1期35-38,共4页
Chinese Pharmacological Bulletin
关键词
千金藤立定碱
哇巴因
乌头碱
氯仿
肾上腺素
心律失常
收缩性
兴奋性
自律性
功能不应期
l-Stepholidine
Ouabain
Aconitine
Chloroform
Adrenaline
Arrhythmia
Contractility
Excitability
Automaticity
Functional refractiry period
