心肌缺血预适应及后适应在再灌注期共同靶点的研究进展

Advances in study of common targets of myocardial ischemic preconditioning and postconditioning during reperfusion

心肌缺血预适应及后适应作为机体的一种内源性保护,分别具有缺血/再灌注损伤保护和再灌注损伤保护功能,尤其是在再灌注期可能存在共同的作用机制,如减少氧自由基生成,激动腺苷受体,募集再灌注损伤营救激酶途径,激活线粒体ATP敏感性钾通道,抑制线粒体渗透性转换孔道开放等。这些共同靶点可以为研制抗再灌注损伤药物提供新的思路。

As a powerful endogenous protection,myocardial ischemic preconditioning and postconditioning have cardioprotection against ischemia reperfusion injury and cardiopretection against reperfusion injury respectively.They perhaps share some mechanisms during reperfusion,such as reduction of the production of oxygen free radical,activation of adenosine receptors,recruit of reperfusion injury salvage kinases,opening of the mitochondrial KATP channel,and inhibition of the mitochondrial permeability transition pore.These common targets may provide new strategy for development of drugs against reperfusion injury.