盐酸克林霉素微囊的体外释药及其影响因素的考察

In Vitro Drug Release of Clindamycin Hydrochloride Microcapsule and its Influencing Factors

目的 采用液中干燥法制备盐酸克林霉素微囊 ,并考察其体外释药特性。方法 以乙基纤维素为囊材制备微囊 ,用桨法研究其体外释药的影响因素。 结果 药物释放速率随微囊粒径减小而增加 ;囊材粘度增加 ,药物释放速率降低 ;附加剂滑石粉对药物释放的影响较复杂 ,随着滑石粉比例增加 ,药物释放速率增加 ,但至一定比例后 ,速率降低。与市售胶囊相比 ,有明显缓释作用。 结论 液中干燥法制备的盐酸克林霉素微囊有显著的缓释作用 。

OBJECTIVE To prepare clindamycin hydrochloride microcapsule by means of intra liquid desiccation and to determine its in vitro drug release.METHODS The microcapsule was prepared using ethyl cellulose as coating material.The influencing factors of in vitro drug release were investigated by paddle method.RESULTS Drug release increased as the particle size of microcapsules decreased.Drug release rate decreased as the viscosity of ethyl cellulose increased.Talc had more complex effects,the release rate increased as the amount of talc increased,then decreased when the amount increased above certain level.The release rate of the prepared microcapsule was slower compared with common clindamycin hydrochloride capsule.CONCLUSION The sustained release behavior is remarkable,it will have a good exploitation.