促红细胞生成素(EPO)在晚期食管癌放疗中增敏作用之观察

Clincal Observation of EPO Combined with Radiation for Esophageal cancer

目的 观察放疗同时使用促细胞生成素对中晚期食管癌的放疗增效作用。方法 2 0 0 0年 3月至 2 0 0 2年 12月 ,采用随机分组对 3 0例中晚期食管癌进行放疗与 EPO同步治疗 ( A组 ) ,并与 3 0例单纯放射治疗组 ( B组 )的结果进行对比。结果 近期疗效 :A组有效率 90 %,B组有效率 73 .3 %。两组对比有显著性差异。 结论

OBJECTIVE To observthe radiao sensibility of EPO.METHODS From March 2000 to December 2002,EPO mused as radiosensitizer combined with radiation to treat esophageal cancer.A total of 60 cases were randomized into two groups, 30 cases were treated by radiotherapy combined with EPO(group A),30 cases were rated by radiotherapy alone(group B). RESULTS Early term response rates were 90% in A group and 73 3% in B group (χ2=4 32,P<0 05). The side effect were found to be mild. CONCLUSION It is suggested the EPO could increase the radiosensibility.