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多嘧啶序列结合蛋白与丙型肝炎病毒的关系 被引量：3

Relations of polypyrimidine tract binding protein and hepatitis C virus
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摘要 0 引言 多嘧啶序列结合蛋白(polypyrimidine tract bindingprotein,PTB),在大多数哺乳动物细胞及人类原始肝细胞的胞核及胞质中均可检测到,其分子量约为57kD,故也有人称之为p57.PTB在稳态时定位于核内[1],且可通过能量依赖机制快速穿梭于细胞的胞质及胞核.
作者 党晓燕 成军 邓红
机构地区 中国人民解放军第 西安交通大学第二医院感染科
出处 《世界华人消化杂志》 CAS 2003年第12期1956-1959,共4页 World Chinese Journal of Digestology
关键词 多嘧啶序列结合蛋白 丙型肝炎病毒 细胞因子 分子生物学机制
分类号 R373.21 [医药卫生—病原生物学]
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参考文献41

  • 1Valcarcel J, Gebauer F. Post-transcriptional regulation: the dawn of PTB. Curr Biol 1997;7:705-708
  • 2Michael WM, Siomi H, Choi M, Pinol-Roma S, Nakielny S, Liu Q, Dreyfuss G. Signal sequences that target nuclear import and nuclear export of pre-mRNA-binding proteins. Cold Spring Harb Syrup Quant Biol 1995;60:663-668
  • 3Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA. Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev 1991;5:1224-1236
  • 4Patton JG, Mayer SA, Tempst P, Nadal-Ginard B. Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for premRNA splicing. Genes Dev 1991;5:1237-1251
  • 5Ghetti A. Pinol-Roma S, Michael WM, Morandi C, Dreyfuss G. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res 1992;20:3671-3678
  • 6Oh YL, Hahm B, Kim YK, Lee HK, Lee JW, Song O, Tsukiyama-Kohara K, Kohara M, Nomoto A, Jang SK. Determination of functional domains in polypyrimidine-tract-binding protein.Biochem J 1998;331:169-175
  • 7Fields S, Song O. A novel genetic system to detect protein-protein interactions. Nature 1989;340:245-246
  • 8Brunel F, Zakin MM, Buc H, Buckle M. The polypyrimidine tract binding (PTB) protein interacts with single-stranded DNA in a sequence-specific manner. Nucleic Acids Res 1996;24:1608-1615
  • 9Wagner EJ, Garcia-Blanco MA. Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 2001;21:3281-32888
  • 10Moreira A, Takagaki Y, Brackenridge S, WoUerton M, Manley JL, Proudfoot NJ. The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formationby two distinct mechanisms. Genes Dev 1998;12:2522-2534

同被引文献65

  • 1许小亮,李君武.丙型肝炎病毒非结构蛋白3蛋白酶抑制剂的研究进展[J].医学研究生学报,2005,18(10):930-933. 被引量：3
  • 2Mazurek S,Boschek C B,Hugo F,et al.Pyruvate kinase typeM2 and its role in tumor growth and spreading[J].Semin Can-cer Biol,2005,15:300-308.
  • 3Christofk H R,Vander Heiden M G,Harris M H,et al.TheM2 splice isoform of pyruvate kinase is important for cancermetabolism and tumour growth[J].Nature,2008,452:230-233.
  • 4Dombrauckas J D,Santarsiero B D,Mesecar A D,et al.Structural basis for tumor pyruvate kinase M2 allosteric regula-tion and catalysis[J].Biochemistry,2005,44:9417-9429.
  • 5Christofk H R,Vander Heiden M G,Wu Ning,et al.Pyruvatekinase M2 is a phosphotyrosine-binding protein[J].Nature,2008,452:181-186.
  • 6Zerbe L K,Pino I,Pio R,et al.Relative amounts of antago-nistic splicing factors,hnRNP A1 and ASF/SF2,change duringneoplastic lung growth:implications for pre-mRNA processing[J].Mol Carcinog,2004,41:187-196.
  • 7Hanamura A,Caceres J F,Mayeda A,et al.Regulatedtissue-specific expression of antagonistic pre-mRNA splicing factors[J].RNA,1998,4(4):430-444.
  • 8Kashima T,Rao N,Marcy J L.An intronic element contributesto splicing repression in spinal muscul atrophy[J].Proc NatlAcad Sci USA,2007,104(9):3426-3431.
  • 9He Y,Brown M A,Rothnagel J A,et al.Roles of heteroge-neous nuclear ribonucleoproteins A and B in cell proliferation[J].J Cell Sci,2005,118(Pt 14):3173-3183.
  • 10Wagner E J,Garcia-Blanco M A.Polypyrimidine tract bindingprotein antagonizes exon definition[J].Mol Cell Biol,2001,21:3281-3288.

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世界华人消化杂志
2003年 第12期

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