摘要0 引言
Shvarts et al[1]报告了一种与p53蛋白结合蛋白的新基因,命名为MDMX,与MDM2蛋白在一级结构上具有同源性,特别是在p53蛋白结合域更是如此.另外,MDM2羧基末端的金属结合域在MDMX分子中也是高度保守的.MDMX蛋白又称为MDM4,是p53的一种结合蛋白,是p53蛋白的负调节因子.
1Shvarts A, Bazuine M, Dekker P, Ramos YF, Steegenga WT,Merckx G, van Ham RC, van der Houven van Oordt W, van der Eb AJ, Jochemsen AG. Isolation and identification of the human homolog of a new p53-binding protein, MDMX.Genomics 1997;43:34-42
2Gentiletti F, Mancini F, D'Angelo M, Sacchi A, Pontecorvi A,Jochemsen AG, Moretti F. MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts.Oncogene 2002;21:867-877
3McCoy MA, Gesell JJ, Senior MM, Wyss DF. Flexible lid to the p53-binding domain of human MDM2:Implications for p53 regulation. Proc Natl Acad Sci USA 2003;100:1645-1648
4Jackson MW, Lindstrom MS, Berberich SJ. MDMX binding to ARF affects MDM2 protein stability and p53 transactivation.J Biol Chem 2001;276:25336-25341
5Migliorini D, Denchi EL, Danovi D, Jochemsen A, Capillo M,Gobbi A, Helin K, Pelicci PG, Marine JC. MDM4 (MDMX)regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002;22:5527-5538
6Riemenschneider MJ, Buschges R, Wolter M, Reitenberger J,Bostrom J, Kraus JA, Schlegel U, Reifenberger G. Amplification and overexpression of the MDM4 (MDMX) gene fromlq32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification. Cancer Res 1999;59:6091-6096
7Badciong JC, Haas AL. MDMX is a RING finger ubiquitin ligase capable of synergistically enhancing MDM2 ubiquitination. J Biol Chem 2002;277:49668-49675
8Stad R, Little NA, Xirodimas DP, Frenk R, van der Eb AJ,Lane DP, Saville MK, Jochemsen AG. MDMX stabilizes p53 and MDM2 via two distinct mechanisms. EMBO Rep 2001;2:1029-1234
9Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A,Ohtsubo M. MDM2 interacts with MDMX through their RING finger domains. FEBS Lett 1999;447:5-9
10Li C, Chen L, Chen J. DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Mol Cell Biol 2002;22:7562-7571
2Zu Hu Huang1,Hui Zhuang2,Shan Lu3,Ren Hua Guo1,Guo Min Xu2,Jie Cai1,Wan Fu Zhu2 1Department of Infectious Diseases. The First Affiliated Hospital of Nanjing Medical University, Nenjing 210029, Jiangsu Province. China2Faculty of Microbiology, Beijing University, Beijing 100000, China3University of Massachusetts Medical Center.Humoral and cellular immunogenecity of DNA vaccine based on hepatitis B core gene in rhesus monkeys[J].World Journal of Gastroenterology,2001,7(1):102-106. 被引量：19
