早期冠脉注射替罗非班在急性心梗患者中的治疗效果分析

Analysis on the Curative Effect of Early Intracoronary Injection of Tirofiban in Patients with Acute Myocardial Infarction

目的探讨早期冠状动脉内注射替罗非班对急性心肌梗死(AMI)患者内皮功能及早期冠脉血流的影响。方法 84例AMI患者随机均分为观察组和对照组。两组均进行介入手术,观察组在此基础上给予冠状动脉内注射替罗非班。结果术后,两组的总有效率无统计学差异(P>0.05),但观察组的显效率显著高于对照组(69.05%vs. 47.62%, P <0.05)。术后,观察组的TIMIⅢ级患者比例显著高于对照组(95.24%vs. 73.81%, P <0.05), s ICAM-1、 sVCAM-1、 vWF、 hs-CRP水平显著低于对照组(P <0.05)。结论早期冠脉注射替罗非班联合介入手术治疗AMI患者能显著提高患者的心功能和内皮功能,疗效显著,安全性高。

Objective To investigate the effects of early intracoronary injection of tirofiban on endothelial function and early coronary blood flow in patients with acute myocardial infarction(AMI).Methods 84 cases of AMI patients were randomly divided into the observation group and the control group equally.Both groups were treated with interventional surgery;in addition,the observation group received intracoronary injection of tirofiban.Results After surgery,no statistical difference was found between the two groups in the total effective rate(P>0.05),while the obviously effective rate of observation group was significantly higher than that of control group(69.05%vs.47.62%,P<0.05).After surgery,the proportion of TIMI classⅢpatients of observation group was significantly higher than that of control group(95.24%vs.73.81%,P<0.05),and the levels of s ICAM-1,s VCAM-1,v WF and hs-CRP were significantly lower than those of control group(P<0.05).Conclusions Early intracoronary injection of tirofiban combined with interventional surgery in the treatment of AMI patients can obviously improve the cardiac function and endothelial function of patients,with significant efficacy and high safety.