白细胞介素1β作为自噬的可观测相关指标与急性淋巴细胞白血病患儿临床特征及预后之间的相关性观察

Correlation between IL-1β as an observable index of autophagy and clinical features and prognosis of children with acute lymphoblastic leukemia

目的观察白细胞介素1β(IL-1β)作为自噬的可观测相关指标与急性淋巴细胞白血病(ALL)患儿临床特征及预后之间的相关性。方法选取该院于2014年8月‐2016年8月收治的60例急性淋巴细胞白血病患儿作为研究对象,以IL-1β含量平均值为界限分为高、低IL-1β水平组,分析IL-1β水平与急性淋巴细胞白血病患儿的临床症状和预后的相关性。结果血清IL-1β水平与ALL患儿的部分临床特征存在显著相关性,如糖皮质激素反应、危险度分级,比较差异具有统计学意义(P <0.05),而与ALL患儿的免疫分型、第15天骨髓幼细胞水平和微小残留病水平、无复发生存率以及确诊后的生存时间等预后指标无显著相关性(P>0.05)。结论 IL-1β作为自噬的可观测相关指标,在一定程度上可以反应ALL患儿的临床症状和预后进展,对于评估患者初期的白血病细胞自噬水平和药物治疗效率需继续深入研究。

【Objective】To observe the correlation between IL-1β as an observable index of autophagy and the clinical features and prognosis of children with acute lymphoblastic leukemia(ALL).【Methods】Sixty children with ALL were selected from August 2014 to August 2016 in our hospital. All patients were divided into high and low IL-1β groups according to the average IL-1β level. The correlation was analyzed between IL-1β level and clinical symptoms and prognosis in children with ALL.【Results】There was a significant correlation between IL-1β level and some clinical features of ALL, such as glucocorticoid response and risk grade, with a statistical difference(P <0.05). There was no significant correlation between IL-1β level and immunophenotyping,bone marrow juvenile cell and minimal residual disease level on the 15 th day, recurrence free survival rate and survival time after diagnosis(P >0.05). 【Conclusion】As an observable marker of autophagy, IL-1β can reflect the clinical symptoms and prognosis of children with ALL to some extent. Further studies are needed to assess the level of autophagy and the efficacy of drug therapy in the early stages of leukemia.